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    Xenoport More Interesting After Washed Out Expectations

    Tue, 04/10/2012 - 00:21 EDT - Seeking Alpha
    • BIIB
    • DEPO
    • GSK
    • Stephen Simpson
    • XNPT

    By Stephen Simpson:It hasn't captured nearly as much attention as Human Genome Sciences and its troubled launch of Benlysta in lupus, but XenoPort (XNPT) too has seen some serious disappointment with the launch of its drug Horizant. While XenoPort's lead drugs are unlikely to ever live up to initial hopes and legal wrangling with its partner Glaxo (GSK) will suck away precious cash, these shares may have been beaten down to a point of value.
    Horizant - Efficacy Not The Issue; Cost-Benefit Is
    Central to the XenoPort story today is the thus far disappointing launch of Horizant - the company's gabapentin prodrug for restless leg. While XenoPort and its partner Glaxo were able to navigate the shoals of the FDA approval process, approval and commercial launch has not been the key to easy money.The issue with Horizant isn't so much about efficacy as it is about cost and the differentiation betweenComplete Story »

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    Related

    • Potential Competition Between Depomed and XenoPort: What Shareholders Should Consider

      Jason Napodano submits: I’ve been thinking about the potential for competition between Depomed’s (DEPO) Gralise (gabapentin extended release) and XenoPort’s (XNPT) Horizant (gabapentin enacarbil). The U.S. PDUFA for Horizant is April 6, 2011. I do not see the two competing head-to-head, at least not for post-herpetic neuralgia (PHN).

    • Xenoport: Favorable Risk/Reward Ratio

      Xenoport (XNPT), a small drug company with a recently-approved drug named Horizant, has a market capitalization of approximately $300m and an enterprise value of approximately $200m. Xenoport is in the business of developing “pro-drugs” – they link existing oral drugs to a transporter molecule that allows good absorption but then disassociates from the drug once it has been absorbed.

    • Investors Can Relax as Human Genome Sciences Moves Closer to Lupus Drug Approval

      The Burrill Report submits: By Michael Fitzhugh

    • Will Human Genome End Up Blazing A Trail For Others?

      By Stephen Simpson:Human Genome Sciences' (HGSI) Benlysta isn't the first would-be blockbuster to disappoint investors with its initial launch, but it's one of the larger disappointments in recent memory.

    • Human Genome Sciences: Slow Benlysta Launch Results In Good Short Candidate

      By Martin Shkreli: Human Genome Sciences (Nasdaq: HGSI) has a market cap of $2.4 billion. Its main asset is Benlysta, a newly approved lupus drug. Because HGS shares half of their gross profit from Benlysta with partner GSK, it is more appropriate to think about the “Benlysta market cap” of roughly $5 billion.

    • Eye on Human Genome Sciences as It Fulfills Its Promise

      Todd Johnson submits:Human Genome Sciences (HGSI) is finally coming to market with the full FDA approved medication. The company's early years hype, and later years near-death stock experience, can all be viewed in perspective.

    • Lupus drug Benlysta an expected blockbuster

      The FDA is expected to make an approval decision this week on a drug that would mean worlds to both the lupus-suffering patient population and to the drug’s developer,

    • Human Genome Sciences Evenly Poised After FDA Approval

      Zacks.com submits: We are maintaining our Neutral recommendation on Human Genome Sciences Inc. (HGSI) with a target price of $29.00.

    • Will Human Genome Sciences’ Lupus Drug Rewards Outweigh the Risks?

      Prohost Biotech submits:A few days before the independent FDA committee review of Human Genome Sciences’ (HGSI) systemic lupus erythematosus (SLE) drug Benlysta (belimumab), the FDA suggested that the drug has marginal efficacy and scary adverse effects.

    • Will Human Genome's Lupus Drug Pass Muster?

      Pharmalot submits: On Tuesday, an FDA advisory panel will review the first new treatment for lupus in decades. And the early indications are that Benlysta, which is being developed by Human Genome Sciences (HGSI), will win an endorsement. At least that’s how some Wall Street analysts are interpreting the FDA briefing documents filed Friday morning, even though the stock is trading down.

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